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Turmeric Spices Up Virus Study

March 8, 2013


By Michele McDonald

Aarthi Narayanan

Aarthi Narayanan

The popular spice turmeric packs more than just flavor—it shows promise in fighting devastating viruses.

Curcumin, found in turmeric, stopped the potentially deadly Rift Valley Fever virus from multiplying in infected cells, says Mason researcher Aarthi Narayanan, lead investigator on a new study.

Mosquito-borne Rift Valley Fever virus is an acute fever-causing virus that affects domestic animals, such as cattle, sheep, and goats, as well as humans. Results of the study were published this month in the Journal of Biological Chemistry.

“Growing up in India, I was given turmeric all the time,” says Narayanan, who has spent 18 months working on the project. “Every time my son has a throat infection, I give [turmeric] to him.”

There’s more work to do before curcumin-based pharmaceuticals become commonplace, Narayanan emphasizes. She plans to test 10 different versions of curcumin to determine which one works the best. She also intends to apply the research to other viruses, including HIV.

Narayanan has long wanted to explore the infection-fighting properties of turmeric, in particular its key component, curcumin. “It is often not taken seriously because it’s a spice,” she says.

But science is transforming the spice from folk medicine to one that could help a patient’s body fight off a virus because it can prevent the virus from taking over healthy cells. These broad-spectrum inhibitors work by defeating a wide array of viruses.

“Curcumin is, by its very nature, broad spectrum,” says Narayanan, who is an assistant research professor in Mason’s National Center for Biodefense and Infectious Diseases. “However, in the published article, we provide evidence that curcumin may interfere with how the virus manipulates the human cell to stop the cell from responding to the infection.”

Her colleague Kylene Kehn-Hall, a co-investigator on the study, adds, “We are very excited about this work, as curcumin not only dramatically inhibits [virus] replication in cell cultures, but also demonstrates efficacy against [the virus] in a mouse model.”

Narayanan and her colleagues study the connection between a virus and how it impacts the host—human or animal. Symptoms clue in the researcher about the body’s inner workings. Rift Valley Fever and Venezuelan Equine Encephalitis kick off with flu-like symptoms.

Mason researcher Aarthi Narayanan working with a graduate student in the National Center for Biodefense and Infectious Diseases lab. Photo by Evan Cantwell.

Mason researcher Aarthi Narayanan working with a graduate student in the National Center for Biodefense and Infectious Diseases lab. Photo by Evan Cantwell.

Symptoms can make it challenging for someone to recover. The body usually starts with an exaggerated inflammatory response because it doesn’t know where to start to rid itself of the virus, she says.

“Many times, the body goes above and beyond what is necessary,” Narayanan says. “And that’s not good because it’s going to influence a bunch of cells around the infection, which haven’t seen the bug. That’s one way by which disease spreads through your body, so it is very important to control the host because a lot of times the way the host responds contributes to the disease.”

Controlling the symptoms means more than simply making patients feel better. “You’re giving the antiviral a chance to work. Now an antiviral can go in and stop the bug. You’re no longer trying to keep the host alive and battling the bug at the same time.”

Once Narayanan knows how the body responds to a virus, it’s time to go after the bug itself.

She’s applying this know-how to a family of viruses called Bunyaviruses, which feature Rift Valley Fever, and such alphaviruses as Venezuelan Equine Encephalitis, and retroviruses, which notably include HIV.

She delves into uncovering why and how each virus affects the patient. “Why are some cell types more susceptible to one type of infection than another?” she asks.

HIV goes after the immune system. Bunyaviruses will infect a wide range of cells but do maximum damage to the liver. “What is it about the liver that makes it a sitting duck compared to something like the brain?” Narayanan asks.

Ultimately, curcumin could be part of drug therapies that help defeat these viruses, Narayanan says.

“I know this works. I know it works because I have seen it happen in real life,” Narayanan says. “I eat it every day. I make it a point of adding it to vegetables I cook. Every single day.”

Other Mason researchers involved in the study are Charles Bailey, Ravi Das, Irene Guendel, Lindsay Hall, Fatah Kashanchi, Svetlana Senina, and Rachel Van Duyne. Several researchers from other institutions also collaborated.


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